A recent research study published in the Journal of Neuroscience tested if supplementation of Resveratrol would enhance memory performance in older adults.
Twenty-three healthy overweight older individuals successfully completed 26 weeks of Resveratrol intake. Before and after the intervention, subjects underwent memory tasks and neuroimaging to assess volume, microstructure, and functional connectivity of the hippocampus, a key region implicated in memory functions. In addition, anthropometry, glucose and lipid metabolism, inflammation, neurotrophic factors, and vascular parameters were measured.
Researchers observed a significant effect of Resveratrol on retention of words over 30 min compared with placebo. In comparison with the placebo group, Resveratrol also showed:
- Significant increases in hippocampal functional connectivity
- Decreases in glycated hemoglobin (HbA1c)
- Decreases in body fat, and
- Increases in leptin